Main Street Newspapers publishes weekly newspapers for surrounding communities such as Salem, Vinton, southwest Roanoke County, and Botetourt County. The theatre delivers four shows a year that are geared towards a family audience. The three modifications L111F, D207N, and R289K probably destabilize the conformational changes that are necessary to maintain the chelatase catalytic cycle. Other stations in the market include Fox affiliate WFXR Fox 21/27 in Roanoke, PBS affiliate WBRA-15 in Roanoke, Liberty University’s WLHG-43 in Lynchburg, independent WFFP-TV-24 in Danville, and ION Television affiliate WPXR-38 in Roanoke. The Roanoke Civic Center’s auditorium and newly renovated theatre, now known as the Roanoke Performing Arts Theatre, host concerts, touring Broadway theatre performances, the Miss Virginia pageant, and other events.